I got both of these errors when I upgraded to VirtualBox 4.1.2! Yikes! Luckily, both were solved for me by fixing the permissions on the /Applications directory. The VirtualBox forums have the details, links below.
sudo chown root /Applications #this fixes VERR_SUPLIB_OWNER_NOT_ROOT, details here) sudo chmod g-w /Applications #this fixes WRITE_SUPLIB_NON_SYS_GROUP, details here)
That was it! Hope this helps if you hit this error.